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2 article(s) from Cloninger, Mary J

Glycodendrimers: tools to explore multivalent galectin-1 interactions

Jonathan M. Cousin and
Mary J. Cloninger

Beilstein J. Org. Chem. 2015, 11, 739–747, doi:10.3762/bjoc.11.84

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Graphical Abstract

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Figure 2: (a) Generation 2 PAMAM dendrimer. (b) Lactose-functionalized dendrimers 1–4. Color-coding correspon...

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Figure 3: Average diameter (nm) of multivalent galectin-1 nanoparticles formed with multivalent glycodendrime...

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Figure 4: Representative fluorescent micrographs of glycodendrimer mediated galectin-1 nanoparticles. Nanopar...

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Figure 5: Comparison of average nanoparticle diameter (nm) formed with 4 measured by FM (blue) and DLS (diago...

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Figure 6: Lactose inhibition of galectin-1 nanoparticle formation with compound 4.

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Figure 7: Cellular aggregation assays with DU145 human prostate carcinoma cells. Cancer cell aggregation assa...

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Figure 8: Schematic representation of galectin-1/glycodendrimer aggregates at varying stoichiometries.

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Full Research Paper

Published 12 May 2015

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Multivalent scaffolds induce galectin-3 aggregation into nanoparticles

Candace K. Goodman,
Mark L. Wolfenden,
Pratima Nangia-Makker,
Anna K. Michel,
Avraham Raz and
Mary J. Cloninger

Beilstein J. Org. Chem. 2014, 10, 1570–1577, doi:10.3762/bjoc.10.162

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Scheme 1: Synthesis of isothiocyanato-functionalized lactoside 1.

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Scheme 2: Synthesis of carbohydrate-functionalized PAMAM dendrimers. (Values for m and for x equivalents adde...

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Figure 1: Effective diameter of galectin-3/glycodendrimer aggregates (DLS). Final concentration of galectin-3...

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Figure 2: Schematic representation of galectin-3/glycodendrimer aggregates at varying stoichiometries.

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Figure 3: Fluorescence microscopy images of labelled particles. Microbead standards at similar exposure times...

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Figure 4: Aggregate diameter distribution of fluorescence microscopy images; 31 μM galectin-3 and 0.14 μM (a) ...

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Published 10 Jul 2014

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